BRAFV600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation
نویسندگان
چکیده
منابع مشابه
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status.
Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and ...
متن کاملThe relationship between the BRAFV600E mutation in papillary thyroid microcarcinoma and clinicopathologic factors
BACKGROUND The BRAF(V600E) mutation, which accounts for about 60-80% papillary thyroid carcinoma(PTC), has been identifiedas a prognostic marker for risk stratification of PTC patients. However, the BRAF(V600E) mutation as a prognostic marker in papillary thyroid microcarcinoma (PTMC) is unclear. METHODS We performed a retrospective review of 101 patients who underwent surgery for PTMC. We st...
متن کاملAssociation between BRAFV600E mutation and the clinicopathological features of solitary papillary thyroid microcarcinoma
The B-Raf proto-oncogene serine/threonine kinase (BRAF)V600E mutation is an important oncogene in the development of papillary thyroid carcinoma (PTC) and has been identified as a risk factor for poor prognosis in patients with PTC. However, whether the BRAFV600E mutation is a prognostic marker in patients with solitary papillary thyroid microcarcinoma (sPTMC) has not yet been established. The ...
متن کاملBRAFV600E mutation and DNA ploidy determination in fine needle aspiration biopsy of papillary thyroid microcarcinoma in a Chinese population
This study aimed to evaluate the diagnostic value of BRAFV600E mutation and DNA ploidy determination for Papillary Thyroid Micro-Carcinoma (PTMC) through fine-needle aspiration. Clinical data, including histology, patient population statistics and clinical results were gathered. Patients’ thyroid-micro-lesions were made into FNA-stained smears, DNA was extracted from the smears for different cy...
متن کاملClinical implication of the BRAFV600E mutation in papillary thyroid carcinoma
BACKGROUND The BRAFV600E mutation is the most common genetic alteration in papillary thyroid carcinoma (PTC). In recent studies, the BRAFV600E mutation has been associated with poor clinicopathological characteristics, such as lymph node metastasis, extrathyroidal extension, and advanced stage. However, other studies have failed to establish an association between the BRAFV600E mutation and cli...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2012
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2012.152